Spatial Metabolomics Services
Spatial metabolomics provides a powerful way to directly visualize metabolites in tissue sections while preserving spatial integrity. Unlike conventional bulk analysis, this approach integrates high-resolution imaging with molecular profiling to reveal tissue-specific metabolic heterogeneity and local biochemical processes.
At Alfa Chemistry, we deliver advanced spatial metabolomics services using state-of-the-art mass spectrometry imaging (MSI) platforms, including MALDI, DESI, and nano-DESI. These complementary technologies ensure broad metabolite coverage, minimal sample preparation, and enhanced sensitivity for low-abundance molecules, all while maintaining tissue morphology.
Service Highlights
High-Resolution Imaging
Our MSI platforms deliver pixel resolutions from 10 to 200 µm, enabling visualization of fine molecular details. MALDI-MSI ensures broad metabolite coverage; DESI-MSI supports simple sample preparation, while nano-DESI provides superior sensitivity for low-abundance molecules.
Broad Sample Compatibility
We support a wide range of biological materials, including fresh-frozen tissues, organoids, partially FFPE-preserved samples, microbial colonies, and plant sections. Optimized preparation strategies—such as sectioning, matrix application, and in situ derivatization—guarantee reliable and reproducible metabolite detection.
Robust Data Workflow
Alfa Chemistry offers an end-to-end pipeline, from project design to advanced bioinformatics. Deliverables include annotated ion maps, statistical reports, and pathway enrichment analyses, provided in vendor-specific and open formats (e.g., imzML) for seamless multi-omics integration.
Key Advantages
- Spatial Integrity – Visualize metabolic gradients and tissue-specific niches.
- Reproducibility – Normalization strategies ensure consistent, quantitative results.
- Expanded Detection – Specialized derivatization enhances coverage of difficult-to-detect metabolites.
Applications
Our spatial metabolomics services empower research across disciplines:
- Oncology – Reveal tumor heterogeneity and identify metabolic biomarkers.
- Neuroscience – Localize neurotransmitter metabolites in brain regions.
- Pharmacology – Track drug metabolism and distribution.
- Microbiology – Map metabolic exchanges within microbial communities.
- Plant & Food Sciences – Analyze nutrient gradients and monitor food quality.
Why Choose Alfa Chemistry
With advanced MSI platforms, extensive expertise, and customizable workflows, Alfa Chemistry provides spatial metabolomics services that deliver reliable, high-resolution insights. Our solutions accelerate biomarker discovery, drug development, and translational research, helping scientists reveal new layers of biological knowledge with confidence.
Please kindly note that our products and services are for research use only.
